Structure of PDB 2qae Chain A

Receptor sequence
>2qaeA (length=465) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
NPYDVVVIGGGPGGYVASIKAAQLGMKTACVEKRGALGGTCLNVGCIPSK
ALLHATHLYHDAHANFARYGLMGGEGVTMDSAKMQQQKERAVKGLTGGVE
YLFKKNKVTYYKGEGSFETAHSIRVNGLDGKQEMLETKKTIIATGSEPTE
LPFLPFDEKVVLSSTGALALPRVPKTMVVIGGGVIGLELGSVWARLGAEV
TVVEFAPRCAPTLDEDVTNALVGALAKNEKMKFMTSTKVVGGTNNGDSVS
LEVEGKRETVTCEALLVSVGRRPFTGGLGLDKINVAKNERGFVKIGDHFE
TSIPDVYAIGDVVDKGPMLAHKAEDEGVACAEILAGKPGHVNYGVIPAVI
YTMPEVASVGKSEDELKKEGVAYKVGKFPFNANSRAKAVSTEDGFVKVLV
DKATDRILGVHIVCTTAGELIGEACLAMEYGASSEDVGRTCHAHPTMSEA
LKEACMALFAKTINF
3D structure
PDB2qae Crystal structure of lipoamide dehydrogenase from Trypanosoma cruzi: A Putative target for the design of new drugs against Chagas disease
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L37 C41 C46 S49 V184 E188 H445 H447 E452
Catalytic site (residue number reindexed from 1) L37 C41 C46 S49 V184 E188 H442 H444 E449
Enzyme Commision number 1.8.1.4: dihydrolipoyl dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A I8 G11 P12 G13 E32 K33 R34 G39 T40 C41 G45 C46 K50 E114 G115 T144 G145 S164 I185 F277 G313 D314 M321 L322 A323 H324 I8 G11 P12 G13 E32 K33 R34 G39 T40 C41 G45 C46 K50 E114 G115 T144 G145 S164 I185 F274 G310 D311 M318 L319 A320 H321
Gene Ontology
Molecular Function
GO:0004148 dihydrolipoyl dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
Cellular Component
GO:0005739 mitochondrion
GO:0045252 oxoglutarate dehydrogenase complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:2qae, PDBe:2qae, PDBj:2qae
PDBsum2qae
PubMed
UniProtP90597|DLDH_TRYCR Dihydrolipoyl dehydrogenase (Gene Name=LPD)

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