Structure of PDB 2qa8 Chain A

Receptor sequence

>2qa8A (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLL
DRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYT
FEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMS
NKGMEHLYSMKCKNVVPLSDLLLEMLDAHR

3D structure

PDB

2qa8 NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

Chain

Resolution

1.85 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	I358 K362 L372 V376 D538 L539 E542	I48 K52 L62 V66 D220 L221 E224
BS02	GEN	A	M343 L346 A350 E353 L387 M421 H524 L525	M33 L36 A40 E43 L77 M111 H206 L207	PDBbind-CN: -logKd/Ki=6.00,IC50=0.99uM BindingDB: IC50=395nM,EC50=240nM,Ki=370nM

External links

PDB	RCSB:2qa8, PDBe:2qa8, PDBj:2qa8
PDBsum	2qa8
PubMed	18344977
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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