Structure of PDB 2qa6 Chain A

Receptor sequence
>2qa6A (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDRPFSEASMMGLLTNLADRELVH
MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAP
NLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQ
LLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL
3D structure
PDB2qa6 NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses
ChainA
Resolution2.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 V376 L379 D538 L539 E542 I52 K56 V70 L73 D232 L233 E236
BS02 KN2 A M343 L346 E353 L387 M421 H524 M37 L40 E47 L81 M115 H218 BindingDB: IC50=48nM,EC50=298nM
External links
PDB RCSB:2qa6, PDBe:2qa6, PDBj:2qa6
PDBsum2qa6
PubMed18344977
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

[Back to BioLiP]