Structure of PDB 2q7d Chain A

Receptor sequence
>2q7dA (length=337) Species: 9606 (Homo sapiens) [Search protein sequence]
KIHHHHHHMQTFLKGKRVGYWLSEKKIKKLNFQAFAELCRKRGMEVVQLN
LSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETI
VLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTM
RLLEKNGLTFPFICKTRVAHGTNSHEMAIVFNQEGLNAPPCVVQNFINHN
AVLYKVFVVGESYTVVQRPSLKNFSDRESIFFNSHNVSKPESSSVLTELD
KIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINA
FPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVAL
3D structure
PDB2q7d Integration of inositol phosphate signaling pathways via human ITPK1.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.134: inositol-tetrakisphosphate 1-kinase.
2.7.1.159: inositol-1,3,4-trisphosphate 5/6-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D295 N297 D297 N299
BS02 MN A D281 D295 D283 D297
BS03 ANP A R106 I155 K157 M169 Q188 F190 I191 H193 S214 L215 S232 S236 D281 I294 D295 N297 R114 I163 K165 M177 Q194 F196 I197 H199 S220 L221 S234 S238 D283 I296 D297 N299
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0047325 inositol-3,4,5,6-tetrakisphosphate 1-kinase activity
GO:0052725 inositol-1,3,4-trisphosphate 6-kinase activity
GO:0052726 inositol-1,3,4-trisphosphate 5-kinase activity
Biological Process
GO:0032957 inositol trisphosphate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2q7d, PDBe:2q7d, PDBj:2q7d
PDBsum2q7d
PubMed17616525
UniProtQ13572|ITPK1_HUMAN Inositol-tetrakisphosphate 1-kinase (Gene Name=ITPK1)

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