Structure of PDB 2q72 Chain A

Receptor sequence
>2q72A (length=511) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence]
KREHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLL
VGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLV
VAIYYVYIESWTLGFAIKFLVGLVPEPPPTDPDSILRPFKEFLYSYIGVP
KGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFIL
AVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTL
SLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAF
FGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTS
SIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDF
WAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYI
TPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAE
RRRNHESAGTL
3D structure
PDB2q72 Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NA A G20 V23 G24 A351 T354 S355 G17 V20 G21 A346 T349 S350
BS02 NA A A22 V23 N27 T254 N286 A19 V20 N24 T249 N281
BS03 LEU A A22 G24 L25 G26 Y108 F253 T254 S256 F259 A19 G21 L22 G23 Y105 F248 T249 S251 F254
BS04 IXX A R30 V33 Q34 A319 F320 D401 R27 V30 Q31 A314 F315 D396 MOAD: ic50=2090uM
PDBbind-CN: -logKd/Ki=2.68,IC50=2.09mM
BS05 IXX A R193 F194 I197 F350 R188 F189 I192 F345 MOAD: ic50=2090uM
PDBbind-CN: -logKd/Ki=2.68,IC50=2.09mM
Gene Ontology
Biological Process
GO:0035725 sodium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:2q72, PDBe:2q72, PDBj:2q72
PDBsum2q72
PubMed17687333
UniProtO67854

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