Structure of PDB 2q6m Chain A

Receptor sequence
>2q6mA (length=201) Species: 666 (Vibrio cholerae) [Search protein sequence]
GSHMAVITPQGVTNWTYQELEATHQALTREGYVFVGYHGTNHVAAQTIVN
RIAPVTENEEKWGGLYVATHAEVAHGYARIKEGTGEYGLPTRAERDARGV
MLRVYIPRASLERFYRTNTPLENAEEHITQVIGHSLPLRNEAFTGPESAG
GEDETVIGWDMAIHAVAIPSTIPGNAYEELAIDEEAVAKEQSISTKPPYK
E
3D structure
PDB2q6m Cholix Toxin, a Novel ADP-ribosylating Factor from Vibrio cholerae.
ChainA
Resolution1.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E581
Catalytic site (residue number reindexed from 1) E154
Enzyme Commision number 2.4.2.36: NAD(+)--diphthamide ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P34 A H460 G461 Y493 A501 Y504 H38 G39 Y66 A74 Y77 MOAD: Kd=0.51uM
BS02 P34 A L449 E452 H591 V593 L27 E30 H164 V166 MOAD: Kd=0.51uM
Gene Ontology
Molecular Function
GO:0047286 NAD+-diphthamide ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:2q6m, PDBe:2q6m, PDBj:2q6m
PDBsum2q6m
PubMed18276581
UniProtQ5EK40|CHXA_VIBCL Cholix toxin (Gene Name=chxA)

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