Structure of PDB 2q6h Chain A

Receptor sequence
>2q6hA (length=512) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence]
VKREHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFL
LVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPL
VVAIYYVYIESWTLGFAIKFLVGLVPEPPPTDPDSILRPFKEFLYSYIGV
PKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFI
LAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFT
LSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVA
FFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLT
SSIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMD
FWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRY
ITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLA
ERRRNHESAGTL
3D structure
PDB2q6h Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
ChainA
Resolution1.85 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NA A G20 V23 G24 A351 T354 S355 G18 V21 G22 A347 T350 S351
BS02 NA A A22 V23 N27 T254 N286 A20 V21 N25 T250 N282
BS03 LEU A A22 G24 G26 Y108 F253 T254 S256 F259 A20 G22 G24 Y106 F249 T250 S252 F255
BS04 CXX A R30 Q34 F320 L400 D401 R28 Q32 F316 L396 D397 MOAD: ic50=250uM
PDBbind-CN: -logKd/Ki=3.60,IC50=250uM
BS05 CXX A R193 F194 I197 F350 R189 F190 I193 F346 MOAD: ic50=250uM
PDBbind-CN: -logKd/Ki=3.60,IC50=250uM
Gene Ontology
Biological Process
GO:0035725 sodium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2q6h, PDBe:2q6h, PDBj:2q6h
PDBsum2q6h
PubMed17687333
UniProtO67854

[Back to BioLiP]