Structure of PDB 2q5k Chain A

Receptor sequence

>2q5kA (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]

PQITLWKRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGI
GGFIKVRQYDQIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

3D structure

PDB

2q5k Design and Synthesis of HIV-1 Protease Inhibitors Incorporating Oxazolidinones as P2/P2' Ligands in Pseudosymmetric Dipeptide Isosteres.

Chain

Resolution

1.95 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D25 T26 G27
Catalytic site (residue number reindexed from 1)	D25 T26 G27
Enzyme Commision number	?

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	AB1	A	D25 G27 A28 D29 G48 P81 I84	D25 G27 A28 D29 G48 P81 I84	MOAD: Ki=0.005nM PDBbind-CN: -logKd/Ki=11.30,Ki=5pM

Gene Ontology

	Molecular Function
GO:0004190	aspartic-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

External links