Structure of PDB 2q58 Chain A

Receptor sequence
>2q58A (length=335) Species: 353152 (Cryptosporidium parvum Iowa II) [Search protein sequence]
YDYTDFINYYDKFKVIVYNVLKKLPLNDEIRKPVIEYYLNCIDYNVKKGK
HIRGKILVLISSLSSAYSNIKRDSIYLLGWVVEAIQALILIADDIMDSGK
FRRGAPCWYIVHGQSNAINDIFFLKMLSLSLIFELSSVFGNDIVMKIQKI
YNESIFFTVLGQHLDLSYFDLSKADKISERYFSMVEMKTSRYTFYMPVFF
GLTLSEIQVSSAQLNLIEAILYKLGEFYQVHNDVSDYLFNDSNADDICRF
KLTWPLQKSFEIADEEMKLKISENYGKNSSLVKDCYNLLKINEHYLEYQR
NALDYLIKLVKDITDDSLQKVFIHLIHQISELITN
3D structure
PDB2q58 Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis
ChainA
Resolution2.37 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1255
Catalytic site (residue number reindexed from 1) D233
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D1115 D1119 D93 D97
BS02 MG A D1115 D1119 D93 D97
BS03 ZOL A D1115 R1124 Q1184 K1210 T1211 Q1251 N1254 D93 R102 Q162 K188 T189 Q229 N232 BindingDB: IC50=30.1nM,Ki=0.050nM
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2q58, PDBe:2q58, PDBj:2q58
PDBsum2q58
PubMed19101474
UniProtQ5CR09

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