Structure of PDB 2q0n Chain A

Receptor sequence
>2q0nA (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
RVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLV
AVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEF
LEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSIL
LTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVD
IWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKG
FLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
3D structure
PDB2q0n Structure of human p21 activating kinase 4 (PAK4) in complex with a consensus peptide.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D440 K442 D444 S445 D458 K467 T478
Catalytic site (residue number reindexed from 1) D143 K145 D147 S148 D161 K170 T181
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A G330 S331 R359 T404 D440 K442 D444 F461 S474 L475 V476 G477 T478 Y480 W481 F516 N517 E518 P520 G33 S34 R62 T107 D143 K145 D147 F164 S177 L178 V179 G180 T181 Y183 W184 F219 N220 E221 P223
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2q0n, PDBe:2q0n, PDBj:2q0n
PDBsum2q0n
PubMed
UniProtO96013|PAK4_HUMAN Serine/threonine-protein kinase PAK 4 (Gene Name=PAK4)

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