Structure of PDB 2q0d Chain A

Receptor sequence
>2q0dA (length=325) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
PSPAVVGRSLVNSFKQFVSHVDATYRLVLDCVAAVDPLMRLYTFGSTVVY
GVHEKGSDVDFVVLNKTDVEDGKGGDAATQVAKGLQADILAKLARVIRQK
HLSWNVEEVRRTRVPVVRVKGGGAVDFDITAYRRNGVRNSALLRAYFEQN
PPCRWLSMSIKRWSKQTGLNASVIGGSITSYGFNLMVVYYLLQRNHLQFV
PPSTIDVSRVEPLPPHLPLEEPADEGLELGTQVLDFLHFFLHEFDSDKQV
ISLNRPGITTKEELDWTKSAEDFARMNGEKVHYQWCIEDPYELNLNVGRN
VTPLKRDFLRRHLEKARDTALLTIV
3D structure
PDB2q0d Dual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferases.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.52: RNA uridylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D66 D68 D58 D60
BS02 ATP A F52 G53 S54 S65 D68 R121 N147 K169 K173 T187 S188 Y189 V305 R307 F44 G45 S46 S57 D60 R113 N139 K161 K165 T179 S180 Y181 V297 R299
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
GO:0050265 RNA uridylyltransferase activity
Biological Process
GO:0071076 RNA 3' uridylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0020023 kinetoplast

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2q0d, PDBe:2q0d, PDBj:2q0d
PDBsum2q0d
PubMed17785418
UniProtQ381M1|TUT4_TRYB2 Terminal uridylyltransferase 4 (Gene Name=TUT4)

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