Structure of PDB 2q0c Chain A

Receptor sequence
>2q0cA (length=327) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
PSPAVVGRSLVNSFKQFVSKRHVDATYRLVLDCVAAVDPLMRLYTFGSTV
VYGVHEKGSDVDFVVLNKTDVEDGKGGDAATQVAKGLQADILAKLARVIR
QKHLSWNVEEVRRTRVPVVRVKGGGAVDFDITAYRRNGVRNSALLRAYFE
QNPPCRWLSMSIKRWSKQTGLNASVIGGSITSYGFNLMVVYYLLQRNHLQ
FVPPSTIDVSRVEPLPPHLPLEEPADEGLELGTQVLDFLHFFLHEFDSDK
QVISLNRPGITTKEELDWTKSAEDFARMNGEKVHYQWCIEDPYELNLNVG
RNVTPLKRDFLRRHLEKARDTALLTIV
3D structure
PDB2q0c Dual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferases.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.52: RNA uridylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D66 D68 D60 D62
BS02 CTP A F52 G53 S54 S65 D68 G144 N147 S148 K169 K173 S188 Y189 F46 G47 S48 S59 D62 G138 N141 S142 K163 K167 S182 Y183
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
GO:0050265 RNA uridylyltransferase activity
Biological Process
GO:0071076 RNA 3' uridylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0020023 kinetoplast

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Biological Process
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Cellular Component
External links
PDB RCSB:2q0c, PDBe:2q0c, PDBj:2q0c
PDBsum2q0c
PubMed17785418
UniProtQ381M1|TUT4_TRYB2 Terminal uridylyltransferase 4 (Gene Name=TUT4)

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