Structure of PDB 2pzf Chain A

Receptor sequence
>2pzfA (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
SLTTTEVVMENVTAFWGGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLM
MIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIGVSYDEYRYRSV
IKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYL
LDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILH
EGSSYFYGTFSELQNLDFSSKLMG
3D structure
PDB2pzf Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T465 Q493 T46 Q74
BS02 ATP A W401 V440 T460 G461 G463 K464 T465 S466 Q493 W16 V21 T41 G42 G44 K45 T46 S47 Q74
BS03 ATP A T547 S549 G550 G551 Q552 T127 S129 G130 G131 Q132
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:2pzf, PDBe:2pzf, PDBj:2pzf
PDBsum2pzf
PubMed20150177
UniProtP13569|CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (Gene Name=CFTR)

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