Structure of PDB 2pxx Chain A

Receptor sequence
>2pxxA (length=213) Species: 9606 (Homo sapiens) [Search protein sequence]
GSGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLG
CGNSALSYELFLGGFPNVTSVDYSSVVVAAMQACYAHVPQLRWETMDVRK
LDFPSASFDVVLEKGTLDALLAGERDPWTVSSEGVHTVDQVLSEVSRVLV
PGGRFISMTSAAPHFRTRHYAQAYYGWSLRHATYGSGFHFHLYLMHKGGK
LSVAQLALGAQIL
3D structure
PDB2pxx An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene.
ChainA
Resolution1.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A W26 Y30 D40 W41 G66 C67 G68 S70 D88 Y89 D113 V114 K130 W10 Y14 D24 W25 G50 C51 G52 S54 D72 Y73 D97 V98 K114
Gene Ontology
Molecular Function
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:2pxx, PDBe:2pxx, PDBj:2pxx
PDBsum2pxx
PubMed19089949
UniProtP0DPD7|EFMT4_HUMAN EEF1A lysine methyltransferase 4 (Gene Name=EEF1AKMT4)

[Back to BioLiP]