Structure of PDB 2pxa Chain A

Receptor sequence
>2pxaA (length=262) Species: 301478 (Murray valley encephalitis virus (strain MVE-1-51)) [Search protein sequence]
RTLGEQWKEKLNAMGKEEFFSYRKEAILEVDRTEARRARREGNKVGGHPV
SRGTAKLRWLVERRFVQPIGKVVDLGCGRGGWSYYAATMKNVQEVRGYTK
GGPGHEEPMLMQSYGWNIVTMKSGVDVFYKPSEISDTLLCDIGESSPSAE
IEEQRTLRILEMVSDWLSRGPKEFCIKILCPYMPKVIEKLESLQRRFGGG
LVRVPLSRNSNHEMYWVSGASGNIVHAVNMTSQVLIGRMDKKIWKGPKYE
EDVNLGSGTRAV
3D structure
PDB2pxa Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A K13 L16 N17 M19 F24 R28 S150 S151 P152 S215 K8 L11 N12 M14 F19 R23 S145 S146 P147 S210
BS02 SAH A S56 G58 G81 C82 G86 W87 T104 K105 D131 V132 F133 D146 I147 S51 G53 G76 C77 G81 W82 T99 K100 D126 V127 F128 D141 I142
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2pxa, PDBe:2pxa, PDBj:2pxa
PDBsum2pxa
PubMed17622627
UniProtP05769|POLG_MVEV5 Genome polyprotein

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