Structure of PDB 2px4 Chain A

Receptor sequence
>2px4A (length=261) Species: 301478 (Murray valley encephalitis virus (strain MVE-1-51)) [Search protein sequence]
RTLGEQWKEKLNAMGKEEFFSYRKEAILEVDRTEARRARREKVGGHPVSR
GTAKLRWLVERRFVQPIGKVVDLGCGRGGWSYYAATMKNVQEVRGYTKGG
PGHEEPMLMQSYGWNIVTMKSGVDVFYKPSEISDTLLCDIGESSPSAEIE
EQRTLRILEMVSDWLSRGPKEFCIKILCPYMPKVIEKLESLQRRFGGGLV
RVPLSRNSNHEMYWVSGASGNIVHAVNMTSQVLIGRMDKKIWKGPKYEED
VNLGSGTRAVG
3D structure
PDB2px4 Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A S56 G81 G86 W87 T104 K105 H110 E111 V130 D131 V132 F133 D146 I147 S49 G74 G79 W80 T97 K98 H103 E104 V123 D124 V125 F126 D139 I140
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2px4, PDBe:2px4, PDBj:2px4
PDBsum2px4
PubMed17622627
UniProtP05769|POLG_MVEV5 Genome polyprotein

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