Structure of PDB 2pwy Chain A

Receptor sequence
>2pwyA (length=251) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence]
GPLLLKDRKGRAYLVFPKEGGVFHHHKGSVPHEALLEAGPGGVVRTHLGE
ELSVHRPTLEEYLLHMKRSATPTYPKDASAMVTLLDLAPGMRVLEAGTGS
GGLTLFLARAVGEKGLVESYEARPHHLAQAERNVRAFWQVENVRFHLGKL
EEAELEEAAYDGVALDLMEPWKVLEKAALALKPDRFLVAYLPNITQVLEL
VRAAEAHPFRLERVLEVGWREWEVRLPVAHPRFQQVGHTAFLVALRRWKG
S
3D structure
PDB2pwy Crystal Structure of Thermus thermophilus tRNA m(1)A(58) Methyltransferase and Biophysical Characterization of Its Interaction with tRNA.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.220: tRNA (adenine(58)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A P76 T77 G101 T102 G103 S104 G106 L107 E125 A126 R127 H130 E155 D170 L171 P72 T73 G97 T98 G99 S100 G102 L103 E121 A122 R123 H126 E151 D166 L167
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0160107 tRNA (adenine(58)-N1)-methyltransferase activity
Biological Process
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0032259 methylation
Cellular Component
GO:0005575 cellular_component
GO:0031515 tRNA (m1A) methyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2pwy, PDBe:2pwy, PDBj:2pwy
PDBsum2pwy
PubMed18262540
UniProtQ8GBB2|TRMI_THET2 tRNA (adenine(58)-N(1))-methyltransferase TrmI (Gene Name=trmI)

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