Structure of PDB 2pvf Chain A

Receptor sequence
>2pvfA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
ELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPVTVAVKML
KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
GNLREYLRARRPPGMEYSYQMTFKDLVSCTYQLARGMEYLASQKCIHRDL
AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFD
RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN
CTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT
3D structure
PDB2pvf A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D626 A628 R630 N631 D644
Catalytic site (residue number reindexed from 1) D149 A151 R153 N154 D167
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D626 R630 L665 P666 W669 V709 D149 R153 L188 P189 W192 V232
BS02 MG A N631 D644 N154 D167
BS03 ACP A L487 G490 F492 G493 V495 A515 K517 A567 N571 L633 D644 L21 G24 F26 G27 V29 A46 K48 A98 N102 L156 D167
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2pvf, PDBe:2pvf, PDBj:2pvf
PDBsum2pvf
PubMed17803937
UniProtP21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)

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