Structure of PDB 2pv7 Chain A

Receptor sequence
>2pv7A (length=276) Species: 727 (Haemophilus influenzae) [Search protein sequence]
GFKTINSDIHKIVIVGGYGKLGGLFARYLRASGYPISILDREDWAVAESI
LANADVVIVSVPINLTLETIERLKPYLTENMLLADLTSVKREPLAKMLEV
HTGAVLGLHPMFGADIASMAKQVVVRCDGRFPERYEWLLEQIQIWGAKIY
QTNATEHDHNMTYIQALRHFSTFANGLHLSKQPINLANLLALSSPIYRLE
LAMIGRLFAQDAELYADIIMNLAVIETLKQTYDEALTFFENNDRQGFIDA
FHKVRDWFGDYSEQFLKESRQLLQQA
3D structure
PDB2pv7 The structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.1.12: prephenate dehydrogenase.
5.4.99.5: chorismate mutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYR A S179 H200 F203 Q256 R297 Q301 Y306 S88 H109 F112 Q165 R206 Q210 Y215
BS02 NAD A G107 G110 K111 L112 D131 R132 W135 S151 V152 P153 I154 T178 S179 F203 L305 G16 G19 K20 L21 D40 R41 W44 S60 V61 P62 I63 T87 S88 F112 L214
Gene Ontology
Molecular Function
GO:0004665 prephenate dehydrogenase (NADP+) activity
GO:0008977 prephenate dehydrogenase (NAD+) activity
GO:0070403 NAD+ binding
Biological Process
GO:0006571 tyrosine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2pv7, PDBe:2pv7, PDBj:2pv7
PDBsum2pv7
PubMed20944228
UniProtP43902|TYRA_HAEIN T-protein (Gene Name=tyrA)

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