Structure of PDB 2pui Chain A

Receptor sequence
>2puiA (length=368) Species: 1423 (Bacillus subtilis) [Search protein sequence]
TPLYETLNESSAVKLGLLTCQEIGDGNLNYVFHIYDRALIIKQAVPPLTI
DRARIESSALIRQGEHVPHLVPRVFYSDTEMAVTVMEDLSHLKIARKGLI
EGENYPHLSQHIGEFLGKTLFYSSDYALEPKVKKQLVKQFTNPELCDITE
RLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKLKKSFLTSAET
LIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALSRD
GADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFE
EAIGFAGCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKR
SEFKTITDVIELFKLLVK
3D structure
PDB2pui Structures of 5-methylthioribose kinase reveal substrate specificity and unusual mode of nucleotide binding
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.100: S-methyl-5-thioribose kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D250 E252 D222 E224
BS02 ADP A N44 I59 K61 L117 S118 I122 F240 D250 N29 I40 K42 L89 S90 I94 F212 D222
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046522 S-methyl-5-thioribose kinase activity
Biological Process
GO:0009086 methionine biosynthetic process
GO:0016310 phosphorylation
GO:0019509 L-methionine salvage from methylthioadenosine

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Molecular Function
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Biological Process
External links
PDB RCSB:2pui, PDBe:2pui, PDBj:2pui
PDBsum2pui
PubMed17522047
UniProtO31663|MTNK_BACSU Methylthioribose kinase (Gene Name=mtnK)

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