Structure of PDB 2pt9 Chain A

Receptor sequence
>2pt9A (length=281) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
KKWFSEFSIMWPGQAFSLKIKKILYETKSKYQNVLVFESTTYGKVLVLDG
VIQLTEKDEFAYHEMMTHVPMTVSKEPKNVLVVGGGDGGIIRELCKYKSV
ENIDICEIDETVIEVSKIYFKNISCGYEDKRVNVFIEDASKFLENVTNTY
DVIIVDSSDPIGPAETLFNQNFYEKIYNALKPNGYCVAQCESLWIHVGTI
KNMIGYAKKLFKKVEYANISIPTYPCGCIGILCCSKTDTGLTKPNKKLES
KEFADLKYYNYENHSAAFKLPAFLLKEIENI
3D structure
PDB2pt9 Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M A Q93 H103 G124 G125 D127 E147 I148 V152 D178 A179 D196 S198 P203 A204 Q53 H63 G84 G85 D87 E107 I108 V112 D138 A139 D156 S158 P163 A164 PDBbind-CN: -logKd/Ki=4.46,IC50=35uM
BS02 2MH A V91 Q93 D199 Y264 V51 Q53 D159 Y224 MOAD: ic50=35uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process
GO:0008295 spermidine biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2pt9, PDBe:2pt9, PDBj:2pt9
PDBsum2pt9
PubMed17822713
UniProtQ8II73

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