Structure of PDB 2psy Chain A

Receptor sequence
>2psyA (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
IINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRV
RLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLNRRIRPT
KDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKR
CEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPC
ARPNRPGVYTNLCKFTKWIQETIQANS
3D structure
PDB2psy Structural basis of the zinc inhibition of human tissue kallikrein 5.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H42 D87 Q176 G177 D178 S179 G180
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H57 H99 D189 S190 C191 S195 S214 W215 G216 D217 H42 H84 D173 S174 C175 S179 S194 W195 G196 D197
BS02 ZN A H96 H99 H81 H84
BS03 ZN A H25 D117 H10 D102
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2psy, PDBe:2psy, PDBj:2psy
PDBsum2psy
PubMed17881000
UniProtQ9Y337|KLK5_HUMAN Kallikrein-5 (Gene Name=KLK5)

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