Structure of PDB 2pix Chain A

Receptor sequence
>2pixA (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIA
RELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB2pix A surface on the androgen receptor that allosterically regulates coactivator binding.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DHT A L701 L704 N705 M745 M749 F764 T877 L31 L34 N35 M75 M79 F94 T207 BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM
BS02 FLF A F673 N727 E829 L830 N833 Y834 E837 F3 N57 E159 L160 N163 Y164 E167 PDBbind-CN: -logKd/Ki=4.30,IC50=50uM
BindingDB: IC50=>50000nM,EC50=67000nM
External links
PDB RCSB:2pix, PDBe:2pix, PDBj:2pix
PDBsum2pix
PubMed17911242
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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