Structure of PDB 2piw Chain A

Receptor sequence
>2piwA (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIA
RELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB2piw A surface on the androgen receptor that allosterically regulates coactivator binding.
ChainA
Resolution2.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DHT A L704 N705 M745 F764 T877 L34 N35 M75 F94 T207 BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM
BS02 T3 A V716 M894 V46 M224
BS03 T3 A I672 G724 N727 E829 N833 Y834 I2 G54 N57 E159 N163 Y164
External links
PDB RCSB:2piw, PDBe:2piw, PDBj:2piw
PDBsum2piw
PubMed17911242
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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