Structure of PDB 2pit Chain A

Receptor sequence
>2pitA (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKW
AKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDL
VFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPV
DGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQP
IARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB2pit A surface on the androgen receptor that allosterically regulates coactivator binding.
ChainA
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DHT A L704 N705 M745 M749 F764 T877 L36 N37 M77 M81 F96 T209 BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM
BS02 4HY A F673 G724 N727 N833 Y834 E837 R840 F5 G56 N59 N165 Y166 E169 R172 BindingDB: IC50=34800nM
External links
PDB RCSB:2pit, PDBe:2pit, PDBj:2pit
PDBsum2pit
PubMed17911242
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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