Structure of PDB 2pir Chain A

Receptor sequence
>2pirA (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKW
AKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDL
VFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPV
DGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQP
IARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB2pir A surface on the androgen receptor that allosterically regulates coactivator binding.
ChainA
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DHT A L704 N705 M745 T877 L36 N37 M77 T209 BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM
BS02 NK A D732 A735 P817 G820 L821 K822 D64 A67 P149 G152 L153 K154
External links
PDB RCSB:2pir, PDBe:2pir, PDBj:2pir
PDBsum2pir
PubMed17911242
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

[Back to BioLiP]