Structure of PDB 2piq Chain A

Receptor sequence
>2piqA (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWA
KALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLV
FNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVD
GLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPI
ARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB2piq A surface on the androgen receptor that allosterically regulates coactivator binding.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DHT A L704 N705 M745 M749 F764 T877 L35 N36 M76 M80 F95 T208 BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM
BS02 RB1 A K720 M734 Q738 I898 K51 M65 Q69 I229
External links
PDB RCSB:2piq, PDBe:2piq, PDBj:2piq
PDBsum2piq
PubMed17911242
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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