Structure of PDB 2pin Chain A

Receptor sequence
>2pinA (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
HKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPGGKVD
LEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSL
RAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFRLGMSLSSFNL
DDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVT
HFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE
3D structure
PDB2pin Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4HY A F269 F272 I276 A317 R320 L330 N331 H435 F54 F57 I61 A102 R105 L115 N116 H220 BindingDB: IC50=0.0407nM
BS02 LEG A K306 L454 K91 L239
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:2pin, PDBe:2pin, PDBj:2pin
PDBsum2pin
PubMed17823305
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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