Structure of PDB 2pe5 Chain A

Receptor sequence
>2pe5A (length=328) Species: 562 (Escherichia coli) [Search protein sequence]
KPVTLYDVAEYAGVSYQTVSRVVNQASHVSAKTREKVEAAMAELNYIPNR
VAQQLAGKQLLLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVER
SGVEACKAAVHNLLAQRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVS
DQTPINSIIFSHEDGTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGW
HKYLTRNQIQPIAEREGDWSAMSGFQQTMQMLNEGIVPTAMLVANDQMAL
GAMRAITESGLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTSV
DRLLQLSQGQAVKGNQLLPVSLVKRKTT
3D structure
PDB2pe5 Structural analysis of lac repressor bound to allosteric effectors
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A S16 Y17 Q18 T19 R22 S31 T34 L56 S15 Y16 Q17 T18 R21 S30 T33 L55
BS02 dna A T5 L6 Q18 Y47 P49 N50 A53 Q54 A57 T4 L5 Q17 Y46 P48 N49 A52 Q53 A56
BS03 145 A L73 A75 P76 F161 R197 W220 N246 D274 Q291 F293 L72 A74 P75 F160 R196 W219 N245 D273 Q290 F292
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001217 DNA-binding transcription repressor activity
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0042802 identical protein binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2pe5, PDBe:2pe5, PDBj:2pe5
PDBsum2pe5
PubMed17543986
UniProtP03023|LACI_ECOLI Lactose operon repressor (Gene Name=lacI)

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