Structure of PDB 2pch Chain A

Receptor sequence
>2pchA (length=265) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
MVLYFIGLGLYDERDITVKGLECAKKCDYVFAEFYTSLMAGTTLGRIQKL
IGKEIRVLSREDVELNFENIVLPLAKENDVAFLTPGDPLVATTHAELRIR
AKRAGVESYVIHAPSIYSAVGITGLHIYKFGKSATVAYPEGNWFPTSYYD
VIKENAERGLHTLLFLDIKAEKRMYMTANEAMELLLKVEDMKKGGVFTDD
TLVVVLARAGSLNPTIRAGYVKDLIREDFGDPPHILIVPGKLHIVEAEYL
VEIAGAPREILRVNV
3D structure
PDB2pch Crystal structure of PH0725 from Pyrococcus horikoshii OT3
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.98: diphthine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A T36 S37 D87 V90 S115 I116 F165 L166 A209 P233 H234 I235 T36 S37 D87 V90 S115 I116 F165 L166 A209 P233 H234 I235
Gene Ontology
Molecular Function
GO:0004164 diphthine synthase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0017183 protein histidyl modification to diphthamide
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2pch, PDBe:2pch, PDBj:2pch
PDBsum2pch
PubMed
UniProtO58456|DPHB_PYRHO Diphthine synthase (Gene Name=dphB)

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