Structure of PDB 2pc8 Chain A

Receptor sequence
>2pc8A (length=394) Species: 5476 (Candida albicans) [Search protein sequence]
AWDYDNNVIRGVNLGGWFVLEPYMTPSLFEPFQNGNDQSGVPVDEYHWTQ
TLGKEAALRILQKHWSTWITEQDFKQISNLGLNFVRIPIGYWAFQLLDND
PYVQGQVQYLEKALGWARKNNIRVWIDLHGAPGSQNGFDNSGLRDSYNFQ
NGDNTQVTLNVLNTIFKKYGGNEYSDVVIGIELLNEPLGPVLNMDKLKQF
FLDGYNSLRQTGSVTPVIIHDAFQVFGYWNNFLTVAEGQWNVVVDHHHYQ
VFSGGELSRNINDHISVACNWGWDAKKESHWNVAGQWSAALTDCAKWLNG
VNRGARYEGAYDNAPYIGSCQPLLDISQWSDEHKTDTRRYIEAQLDAFEY
TGGWVFWSWKTENAPEWSFQTLTYNGLFPQPVTDRQFPNQCGFH
3D structure
PDB2pc8 Carbohydrate binding sites in Candida albicans exo-beta-1,3-glucanase and the role of the Phe-Phe 'clamp' at the active site entrance.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E192 Q292
Catalytic site (residue number reindexed from 1) E186 Q286
Enzyme Commision number 2.4.1.-
3.2.1.58: glucan 1,3-beta-glucosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BGC A W246 N247 V248 S285 H286 W287 W240 N241 V242 S279 H280 W281
Gene Ontology
Molecular Function
GO:0004338 glucan exo-1,3-beta-glucosidase activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0016740 transferase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0000272 polysaccharide catabolic process
GO:0005975 carbohydrate metabolic process
GO:0006696 ergosterol biosynthetic process
GO:0007155 cell adhesion
GO:0009251 glucan catabolic process
GO:0031505 fungal-type cell wall organization
GO:0031589 cell-substrate adhesion
GO:0044011 single-species biofilm formation on inanimate substrate
GO:0044042 glucan metabolic process
GO:0044407 single-species biofilm formation in or on host organism
GO:0071555 cell wall organization
Cellular Component
GO:0005576 extracellular region
GO:0009986 cell surface
GO:1903561 extracellular vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2pc8, PDBe:2pc8, PDBj:2pc8
PDBsum2pc8
PubMed20875088
UniProtP29717|EXG1_CANAL Glucan 1,3-beta-glucosidase (Gene Name=XOG1)

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