Structure of PDB 2pc2 Chain A

Receptor sequence

>2pc2A (length=129) Species: 9031 (Gallus gallus)

KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGS
TDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVS
DGNGMNAWVAWRNRCKGTDVQAWIRGCRL

3D structure

• PDB: 2pc2 A dipicolinate lanthanide complex for solving protein structures using anomalous diffraction
• Chain: A
• Resolution: 1.538 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): E35 N46 D48 S50 D52 N59
• Catalytic site (residue number reindexed from 1): E35 N46 D48 S50 D52 N59
• Enzyme Commision number: 3.2.1.17: lysozyme.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PDC	A	C6 C127 R128	C6 C127 R128
BS02	PDC	A	G4 R5 C6 E7	G4 R5 C6 E7
BS03	PDC	A	R125 G126	R125 G126
BS04	PDC	A	R125 G126	R125 G126
BS05	PDC	A	R61 W62	R61 W62
BS06	PDC	A	R21 G22 Y23	R21 G22 Y23

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0005515 protein binding
• GO:0016231 beta-N-acetylglucosaminidase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0042802 identical protein binding

Biological Process

• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0050829 defense response to Gram-negative bacterium
• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum

External links

• PDB: RCSB:2pc2, PDBe:2pc2, PDBj:2pc2
• PDBsum: 2pc2
• PubMed: 18350532
• UniProt: P00698|LYSC_CHICK Lysozyme C (Gene Name=LYZ)