Structure of PDB 2pau Chain A

Receptor sequence
>2pauA (length=176) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
SHFFAHLSRLKLINRWPLMRNVRTENVSEHSLQVAMVAHALAAIKNRKFG
GNVNAERIALLAMYHDASAVLTGDLPTPIAQEYKAIEKIAQQKLVDMVPE
ELRDIFAPLIDEHAYSDEEKSLVKQADALCAYLKCLEELAAGNNEFLLAK
TRLEATLEARRSQEMDYFMEIFVPSF
3D structure
PDB2pau Structural insight into the mechanism of substrate specificity and catalytic activity of an HD-domain phosphohydrolase: the 5'-deoxyribonucleotidase YfbR from Escherichia coli.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.89: 5'-deoxynucleotidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO A H33 H68 D69 D137 H30 H65 D66 D127
BS02 D5M A R18 W19 H33 D77 T80 D137 R15 W16 H30 D74 T77 D127
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0002953 5'-deoxynucleotidase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0050340 thymidylate 5'-phosphatase activity
GO:0050897 cobalt ion binding
Biological Process
GO:0006226 dUMP biosynthetic process
GO:0010139 pyrimidine deoxyribonucleotide salvage
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2pau, PDBe:2pau, PDBj:2pau
PDBsum2pau
PubMed18353368
UniProtP76491|5DNU_ECOLI 5'-deoxynucleotidase YfbR (Gene Name=yfbR)

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