Structure of PDB 2paa Chain A

Receptor sequence

>2paaA (length=413) Species: 10090 (Mus musculus)

AKLTLDKVDLKGKRVIMRVDFNVPMKNNQITNNQRIKAAIPSIKHCLDNG
AKSVVLMSHLGRPDGIPMPDKYSLEPVADELKSLLNKDVIFLKDCVGPEV
EQACANPDNGSIILLENLRFHVEEEGKGKDSSGKKISADPAKVEAFRASL
SKLGDVYVNDAFGTAHRAHSSMVGVNLPQKASGFLMKKELDYFSKALEKP
ERPFLAILGGAKVKDKIQLIKNMLDKVNFMIIGGGMAYTFLKELKNMQIG
ASLFDEEGATIVKEIMEKAEKNGVKIVFPVDFVTGDKFDENAKVGQATIE
SGIPSGWMGLDCGPESIKINAQIVAQAKLIVWNGPIGVFEWDAFAKGTKA
LMDEVVKATSNGCVTIIGGGDTATCCAKWGTEDKVSHVSTGGGASLELLE
GKILPGVEALSNM

3D structure

• PDB: 2paa X-ray analysis of phosphoglycerate kinase 2, a sperm-specific isoform from Mus musculus.
• Chain: A
• Resolution: 2.7 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R38 K215 G373 G396
• Catalytic site (residue number reindexed from 1): R35 K212 G370 G393
• Enzyme Commision number: 2.7.2.3: phosphoglycerate kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	A	G213 A214 K219 G238 L256 G312 L313 G337 G340 V341 E343 D374	G210 A211 K216 G235 L253 G309 L310 G334 G337 V338 E340 D371

Gene Ontology

Molecular Function

• GO:0004618 phosphoglycerate kinase activity
• GO:0005524 ATP binding
• GO:0016301 kinase activity

Biological Process

• GO:0006096 glycolytic process
• GO:0016310 phosphorylation
• GO:0030317 flagellated sperm motility

Cellular Component

• GO:0005737 cytoplasm
• GO:0005929 cilium
• GO:0035686 sperm fibrous sheath

External links

• PDB: RCSB:2paa, PDBe:2paa, PDBj:2paa
• PDBsum: 2paa
• PubMed: 18004764
• UniProt: P09041|PGK2_MOUSE Phosphoglycerate kinase 2 (Gene Name=Pgk2)