Structure of PDB 2p9c Chain A

Receptor sequence
>2p9cA (length=405) Species: 562 (Escherichia coli) [Search protein sequence]
LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAH
FIGLRSRTHLTEDVINAAEKLVAIGAFAIGTNQVDLDAAAKRGIPVFNAP
FSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLG
IIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSD
VVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALADALAS
KHLAGAAIDVFPTEPATNSDPFTSPLAEFDNVLLTPHIGGSTQEAQENIG
LEVAGKLIKYSDNGSTLSAVNFPEVSLPLHVGRRLMHIHENRPGVLTALN
KIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIR
ARLLY
3D structure
PDB2p9c The Effect of Hinge Mutations on Effector Binding and Domain Rotation in Escherichia coli D-3-Phosphoglycerate Dehydrogenase
ChainA
Resolution2.46 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N108 R240 D264 E269 H292
Catalytic site (residue number reindexed from 1) N103 R235 D259 E264 H287
Enzyme Commision number 1.1.1.399: 2-oxoglutarate reductase.
1.1.1.95: phosphoglycerate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI A I84 V112 G160 H161 I162 Y180 D181 I182 H210 V211 P212 A238 S239 R240 H292 G294 I79 V107 G155 H156 I157 Y175 D176 I177 H205 V206 P207 A233 S234 R235 H287 G289
BS02 SER A H344 N346 R347 L351 L370 H339 N341 R342 L346 L365
Gene Ontology
Molecular Function
GO:0004617 phosphoglycerate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042802 identical protein binding
GO:0047545 2-hydroxyglutarate dehydrogenase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding
GO:0070404 NADH binding
GO:0070905 serine binding
Biological Process
GO:0006564 L-serine biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2p9c, PDBe:2p9c, PDBj:2p9c
PDBsum2p9c
PubMed17459882
UniProtP0A9T0|SERA_ECOLI D-3-phosphoglycerate dehydrogenase (Gene Name=serA)

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