Structure of PDB 2p8u Chain A

Receptor sequence
>2p8uA (length=462) Species: 9606 (Homo sapiens) [Search protein sequence]
NLYFQSMDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGF
CTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNL
MQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAG
DIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPD
MLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLNDF
GFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLED
TYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLA
QYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDL
KSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRV
DEKHRRTYARRP
3D structure
PDB2p8u Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P27 Y84 D85
Catalytic site (residue number reindexed from 1) P19 Y76 D77
Enzyme Commision number 2.3.3.10: hydroxymethylglutaryl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A G45 K46 G50 Y163 N167 A168 T171 S221 P266 Y267 K269 L270 K273 G37 K38 G42 Y155 N159 A160 T163 S213 P258 Y259 K261 L262 K265
Gene Ontology
Molecular Function
GO:0004421 hydroxymethylglutaryl-CoA synthase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006084 acetyl-CoA metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:2p8u, PDBe:2p8u, PDBj:2p8u
PDBsum2p8u
PubMed20346956
UniProtQ01581|HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthase, cytoplasmic (Gene Name=HMGCS1)

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