Structure of PDB 2p8n Chain A

Receptor sequence
>2p8nA (length=258) Species: 3988 (Ricinus communis) [Search protein sequence]
YPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQ
RFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAIT
HLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYS
TGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVI
TLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALM
VYRCAPPP
3D structure
PDB2p8n Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site
ChainA
Resolution1.94 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V81 E177 R180
Catalytic site (residue number reindexed from 1) V76 E172 R175
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADE A Y80 V81 G121 Y123 I172 R180 Y75 V76 G116 Y118 I167 R175 MOAD: Kd=0.7mM
PDBbind-CN: -logKd/Ki=3.15,Kd=0.7mM
Gene Ontology
Molecular Function
GO:0030598 rRNA N-glycosylase activity
Biological Process
GO:0017148 negative regulation of translation

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Molecular Function
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Biological Process
External links
PDB RCSB:2p8n, PDBe:2p8n, PDBj:2p8n
PDBsum2p8n
PubMed17986339
UniProtP02879|RICI_RICCO Ricin

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