Structure of PDB 2p6e Chain A

Receptor sequence
>2p6eA (length=442) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
DKAKKLENLLKLLQLNNDDTSKFDHKFWRTQPVKDFDEKVVEEGPIDKPK
TPEDISDKPLPLLSSFEWCSIDVDNKKQLEDVFVLLNENYVEDRDAGFRF
NYTKEFFNWALKSPGWKKDWHIGVRVKETQKLVAFISAIPVTLGVRGKQV
PSVEINFLCVHKQLRSKRLTPVLIKEITRRVNKCDIWHALYTAGIVLPAP
VSTCRYTHRPLNWKKLYEVDFTGLPDGHTEEDMIAENALPAKTKTAGLRK
LKKEDIDQVFELFKRYQSRFELIQIFTKEEFEHNFIGEESLPLDKQVIFS
YVVEQPDGKITDFFSFYSLPFTILNNTKYKDLGIGYLYYYATDADFQFKD
RFDPKATKALKTRLCELIYDACILAKNANMDVFNALTSQDNTLFLDDLKF
GPGDGFLNFYLFNYRAKPITGGLNPDNSNDIKRRSNVGVVML
3D structure
PDB2p6e Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N169 F170 L171 T205 L455
Catalytic site (residue number reindexed from 1) N156 F157 L158 T192 L442
Enzyme Commision number 2.3.1.97: glycylpeptide N-tetradecanoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MYA A F27 H38 F40 W41 Y103 I168 L171 V173 R178 S179 R181 T183 I187 T191 V194 H201 Y204 I208 L210 F425 F23 H25 F27 W28 Y90 I155 L158 V160 R165 S166 R168 T170 I174 T178 V181 H188 Y191 I195 L197 F412
Gene Ontology
Molecular Function
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006499 N-terminal protein myristoylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2p6e, PDBe:2p6e, PDBj:2p6e
PDBsum2p6e
PubMed17513302
UniProtP14743|NMT_YEAST Glycylpeptide N-tetradecanoyltransferase (Gene Name=NMT1)

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