Structure of PDB 2p4t Chain A

Receptor sequence
>2p4tA (length=58) Species: 562 (Escherichia coli) [Search protein sequence]
NATFGMGDRVRKKSGAAWQGQIVGWYCTNLTPEGYAVESEAHPGSVHIYP
VAALERIN
3D structure
PDB2p4t Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode.
ChainA
Resolution1.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K32 H67 I68 Y69
Catalytic site (residue number reindexed from 1) K12 H47 I48 Y49
Enzyme Commision number 1.5.1.3: dihydrofolate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A K32 A36 V66 H67 Y69 K12 A16 V46 H47 Y49 MOAD: Kd=0.027uM
Gene Ontology
Molecular Function
GO:0004146 dihydrofolate reductase activity
Biological Process
GO:0009410 response to xenobiotic stimulus

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Molecular Function
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Biological Process
External links
PDB RCSB:2p4t, PDBe:2p4t, PDBj:2p4t
PDBsum2p4t
PubMed17473013
UniProtP00383|DYR21_ECOLX Dihydrofolate reductase type 2

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