Structure of PDB 2p4q Chain A

Receptor sequence
>2p4qA (length=476) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MSADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANEAKGKS
IIGATSIEDFISKLKRPRKVMLLVKAGAPVDALINQIVPLLEKGDIIIDG
GNSHFPDSNRRYEELKKKGILFVGSGVSGGEEGARYGPSLMPGGSEEAWP
HIKNIFQSISAKSDGEPCCEWVGPAGAGHYVKMVHNGIEYGDMQLICEAY
DIMKRLGGFTDKEISDVFAKWNNGVLDSFLVEITRDILKFDDVDGKPLVE
KIMDTAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSALKNERIRASK
VLPGPEVPKDAVKDREQFVDDLEQALYASKIISYAQGFMLIREAAATYGW
KLNNPAIALMWRGGCIIRSVFLGQITKAYREEPDLENLLFNKFFADAVTK
AQSGWRKSIALATTYGIPTPAFSTALSFYDGYRSERLPANLLQAQRDYFG
AHTFRVLPECASDNLPVDKDIHINWT
3D structure
PDB2p4q Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1
ChainA
Resolution2.37 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S128 K182 H185 N186 E189
Catalytic site (residue number reindexed from 1) S128 K182 H185 N186 E189
Enzyme Commision number 1.1.1.44: phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FLC A E189 Y190 Q258 K259 R286 E189 Y190 Q258 K259 R286
BS02 FLC A N102 S128 K182 N186 E189 I366 N102 S128 K182 N186 E189 I366
Gene Ontology
Molecular Function
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0006098 pentose-phosphate shunt
GO:0009051 pentose-phosphate shunt, oxidative branch
GO:0019521 D-gluconate metabolic process
GO:0034599 cellular response to oxidative stress
GO:0046177 D-gluconate catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:2p4q, PDBe:2p4q, PDBj:2p4q
PDBsum2p4q
PubMed17570834
UniProtP38720|6PGD1_YEAST 6-phosphogluconate dehydrogenase, decarboxylating 1 (Gene Name=GND1)

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