Structure of PDB 2p3o Chain A

Receptor sequence
>2p3oA (length=258) Species: 11060 (dengue virus type 2) [Search protein sequence]
ETLGEKWKSRLNALGKSEFQIYKKSGIQEVDRTLAKEGIKRGETDHHAVS
RGSAKLRWFVERNLVTPEGKVVDLGCGRGGWSYYCGGLKNVREVKGLTKG
GPGHEEPIPMSTYGWNLVRLQSGVDVFFIPPERCDTLLCDIGESSPNPTV
EAGRTLRVLNLVENWLSNNTQFCVKVLNPYMSSVIEKMEALQRKHGGALV
RNPLSRNSTHEMYWVSNASGNIVSSVNMISRMLINRFTMRHKKATYEPDV
DLGSGTRN
3D structure
PDB2p3o Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
ChainA
Resolution2.756 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A S56 G81 G86 W87 T104 K105 D131 V132 F133 D146 S50 G75 G80 W81 T98 K99 D125 V126 F127 D140
BS02 GTA A K14 L17 N18 F25 S150 S151 K8 L11 N12 F19 S144 S145 PDBbind-CN: -logKd/Ki=2.77,IC50=1.7mM
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2p3o, PDBe:2p3o, PDBj:2p3o
PDBsum2p3o
PubMed17686489
UniProtQ9WLZ5

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