Structure of PDB 2p3a Chain A

Receptor sequence
>2p3aA (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PQITLWKRPLVTIKIGGQLKEALLDTGADDTVLEEMALPGKWKPRMIGGI
GGFVKVRQYDQIPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF
3D structure
PDB2p3a Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D25 T26 G27
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number 3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3TL A D25 G27 D29 R45 M46 I47 G48 I50 P81 I84 D25 G27 D29 R45 M46 I47 G48 I50 P81 I84 MOAD: Ki=11nM
PDBbind-CN: -logKd/Ki=7.96,Ki=11nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2p3a, PDBe:2p3a, PDBj:2p3a
PDBsum2p3a
PubMed17467738
UniProtQ6BB74

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