Structure of PDB 2p2j Chain A

Receptor sequence
>2p2jA (length=633) [Search protein sequence]
HKHAIPANIADRCLINPEQYETKYKQSINDPDTFWGEQGKILDWITPYQK
VKNTSFAPGNVSIKWYEDGTLNLAANCLDRHLQENGDRTAIIWEGDDTSQ
SKHISYRELHRDVCRFANTLLDLGIKKGDVVAIYMPMVPEAAVAMLACAR
IGAVHSVIFGGFSPEAVAGRIIDSSSRLVITADEGVRAGRSIPLKKNVDD
ALKNPNVTSVEHVIVLKRTGSDIDWQEGRDLWWRDLIEKASPEHQPEAMN
AEDPLFILYTSGSTGKPKGVLHTTGGYLVYAATTFKYVFDYHPGDIYWCT
ADVGWVTGHSYLLYGPLACGATTLMFEGVPNWPTPARMCQVVDKHQVNIL
YTAPTAIRALMAEGDKAIEGTDRSSLRILGSVGEPINPEAWEWYWKKIGK
EKCPVVDTWWQTETGGFMITPLPGAIELKAGSATRPFFGVQPALVDNEGH
PQEGATEGNLVITDSWPGQARTLFGDHERFEQTYFSTFKNMYFSGDGARR
DEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGIPHAI
KGQAIYAYVTLNHGEEPSPELYAEVRNWVRKEIGPLATPDVLHWTDSLPK
TRSGAIMRRILRKIAAGDADPGVVEKLLEEKQA
3D structure
PDB2p2j Biochemical and Crystallographic Analysis of Substrate Binding and Conformational Changes in Acetyl-CoA Synthetase.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T264 T416 E417 N521 R526 A609
Catalytic site (residue number reindexed from 1) T260 T412 E413 N517 R522 A605
Enzyme Commision number 6.2.1.1: acetate--CoA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A F163 G164 G165 R191 I196 W309 T311 A357 T359 A360 S523 R584 F159 G160 G161 R187 I192 W305 T307 A353 T355 A356 S519 R580
BS02 PRX A V386 G387 E388 P389 T412 W413 W414 Q415 T416 D500 I512 R515 R526 V382 G383 E384 P385 T408 W409 W410 Q411 T412 D496 I508 R511 R522
Gene Ontology
Molecular Function
GO:0003987 acetate-CoA ligase activity
GO:0005524 ATP binding
GO:0016208 AMP binding
GO:0016874 ligase activity
GO:0016877 ligase activity, forming carbon-sulfur bonds
GO:0046872 metal ion binding
Biological Process
GO:0006085 acetyl-CoA biosynthetic process
GO:0006935 chemotaxis
GO:0019427 acetyl-CoA biosynthetic process from acetate
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2p2j, PDBe:2p2j, PDBj:2p2j
PDBsum2p2j
PubMed17497934
UniProtQ8ZKF6|ACSA_SALTY Acetyl-coenzyme A synthetase (Gene Name=acs)

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