Structure of PDB 2p2f Chain A

Receptor sequence
>2p2fA (length=637) [Search protein sequence]
KHAIPANIADRCLINPEQYETKYKQSINDPDTFWGEQGKILDWITPYQKV
KNTSFAPGNVSIKWYEDGTLNLAANCLDRHLQENGDRTAIIWEGDDTSQS
KHISYRELHRDVCRFANTLLDLGIKKGDVVAIYMPMVPEAAVAMLACARI
GAVHSVIFGGFSPEAVAGRIIDSSSRLVITADEGVRAGRSIPLKKNVDDA
LKNPNVTSVEHVIVLKRTGSDIDWQEGRDLWWRDLIEKASPEHQPEAMNA
EDPLFILYTSGSTGKPKGVLHTTGGYLVYAATTFKYVFDYHPGDIYWCTA
DVGWVTGHSYLLYGPLACGATTLMFEGVPNWPTPARMCQVVDKHQVNILY
TAPTAIRALMAEGDKAIEGTDRSSLRILGSVGEPINPEAWEWYWKKIGKE
KCPVVDTWWQTETGGFMITPLPGAIELKAGSATRPFFGVQPALVDNEGHP
QEGATEGNLVITDSWPGQARTLFGDHERFEQTYFSTFKNMYFSGDGARRD
EDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGIPHAIK
GQAIYAYVTLNHGEEPSPELYAEVRNWVRKEIGPLATPDVLHWTDSLPKT
RSGKIMRRILRKIAAGDTSSTLADPGVVEKLLEEKQA
3D structure
PDB2p2f Biochemical and Crystallographic Analysis of Substrate Binding and Conformational Changes in Acetyl-CoA Synthetase.
ChainA
Resolution2.58 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T264 T416 E417 N521 R526 K609
Catalytic site (residue number reindexed from 1) T259 T411 E412 N516 R521 K604
Enzyme Commision number 6.2.1.1: acetate--CoA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A F163 R191 W309 T311 P334 A357 A360 S523 R584 P589 F158 R186 W304 T306 P329 A352 A355 S518 R579 P584
BS02 AMP A G387 E388 P389 T412 W413 W414 Q415 T416 D500 I512 R515 N521 R526 G382 E383 P384 T407 W408 W409 Q410 T411 D495 I507 R510 N516 R521
Gene Ontology
Molecular Function
GO:0003987 acetate-CoA ligase activity
GO:0005524 ATP binding
GO:0016208 AMP binding
GO:0016874 ligase activity
GO:0016877 ligase activity, forming carbon-sulfur bonds
GO:0046872 metal ion binding
Biological Process
GO:0006085 acetyl-CoA biosynthetic process
GO:0006935 chemotaxis
GO:0019427 acetyl-CoA biosynthetic process from acetate
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2p2f, PDBe:2p2f, PDBj:2p2f
PDBsum2p2f
PubMed17497934
UniProtQ8ZKF6|ACSA_SALTY Acetyl-coenzyme A synthetase (Gene Name=acs)

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