Structure of PDB 2p1t Chain A

Receptor sequence
>2p1tA (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
DMPVERILEAELAVEDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQ
VILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFD
RVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVY
ASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPI
DTFLMEMLEAP
3D structure
PDB2p1t Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V280 K284 V298 L301 R302 T449 E453 V33 K37 V51 L54 R55 T202 E206
BS02 3TN A I268 A272 Q275 N306 L309 F313 R316 L326 A327 H435 I21 A25 Q28 N59 L62 F66 R69 L79 A80 H188
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2p1t, PDBe:2p1t, PDBj:2p1t
PDBsum2p1t
PubMed17947383
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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