Structure of PDB 2p15 Chain A

Receptor sequence
>2p15A (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYRPFSEASMMGLLTNLADRELVHM
INWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPN
LLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSG
VYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQL
LLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL
3D structure
PDB2p15 Structural plasticity in the oestrogen receptor ligand-binding domain.
ChainA
Resolution1.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 D538 L539 E542 M543 I51 K55 L65 D231 L232 E235 M236
BS02 EZT A M343 L346 E353 L387 F404 V418 M421 I424 F425 H524 M36 L39 E46 L80 F97 V111 M114 I117 F118 H217 PDBbind-CN: -logKd/Ki=10.30,Kd=50pM
External links
PDB RCSB:2p15, PDBe:2p15, PDBj:2p15
PDBsum2p15
PubMed17468738
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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