Structure of PDB 2p0e Chain A

Receptor sequence
>2p0eA (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]
VPRGSKTFIIGISGVTNSGKTTLAKNLQKHLPNCSVISQDDFFKPESEIE
TDKNGFLQYDVLEALNMEKMMSAISCWMESARHSVVSTDQEEIPILIIEG
FLLFNYKPLDTIWNRSYFLTIPYEECKRRRSTRVYQPPDSPGYFDGHVWP
MYLKYRQEMQDITWEVVYLDGTKSEEDLFLQVYEDLIQEL
3D structure
PDB2p0e Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD(+).
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.173: nicotinate riboside kinase.
2.7.1.22: ribosylnicotinamide kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TIZ A D35 F38 Y54 D55 F99 R128 D40 F43 Y59 D60 F101 R130
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0034317 nicotinate riboside kinase activity
GO:0046872 metal ion binding
GO:0050262 ribosylnicotinamide kinase activity
GO:0061769 ribosylnicotinate kinase activity
Biological Process
GO:0009435 NAD biosynthetic process
GO:0016310 phosphorylation
GO:0019363 pyridine nucleotide biosynthetic process
GO:0019674 NAD metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2p0e, PDBe:2p0e, PDBj:2p0e
PDBsum2p0e
PubMed17914902
UniProtQ9NWW6|NRK1_HUMAN Nicotinamide riboside kinase 1 (Gene Name=NMRK1)

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