Structure of PDB 2p0c Chain A

Receptor sequence
>2p0cA (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
NKLEDVVIDRNLLILGKILGEFGSVMEGNLKQEDGTSLKVAVKTMEFLSE
AACMKDFSHPNVIRLLGVCIPKPMVILPFMKYGDLHTYLLYSRLETGPKH
IPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGL
PVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDY
LLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL
3D structure
PDB2p0c Structural insights into the inhibited states of the Mer receptor tyrosine kinase.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D723 A725 R727 N728 D741
Catalytic site (residue number reindexed from 1) D129 A131 R133 N134 D147
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N728 D741 N134 D147
BS02 ANP A V601 A617 P672 F673 M674 D723 N728 D741 V25 A41 P78 F79 M80 D129 N134 D147
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2p0c, PDBe:2p0c, PDBj:2p0c
PDBsum2p0c
PubMed19028587
UniProtQ12866|MERTK_HUMAN Tyrosine-protein kinase Mer (Gene Name=MERTK)

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