Structure of PDB 2ozu Chain A

Receptor sequence
>2ozuA (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
RCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQH
MKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTL
YYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRK
GYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQ
SIKKLSKLTGICPQDITSTLHHLRMLIRREKLIQDHMAKLQLRPVDVDPE
CLRW
3D structure
PDB2ozu The crystal structure of human MYST histone acetyltransferase 3 in complex with acetylcoenzyme A
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C646 E680
Catalytic site (residue number reindexed from 1) C140 E174
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C540 C543 H556 C560 C34 C37 H50 C54
BS02 ACO A F600 L601 I647 M648 I649 Q654 R655 G657 G659 R660 L683 S684 L686 G687 S690 F94 L95 I141 M142 I143 Q148 R149 G151 G153 R154 L177 S178 L180 G181 S184
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:2ozu, PDBe:2ozu, PDBj:2ozu
PDBsum2ozu
PubMed
UniProtQ92794|KAT6A_HUMAN Histone acetyltransferase KAT6A (Gene Name=KAT6A)

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