Structure of PDB 2oz7 Chain A

Receptor sequence

>2oz7A (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]

PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIA
RELHQFAFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ

3D structure

PDB

2oz7 Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design.

Chain

Resolution

1.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA4	A	L704 N705 L707 Q711 M742 F764 M780 F876 A877 L880 F891	L34 N35 L37 Q41 M72 F94 M110 F206 A207 L210 F221	PDBbind-CN: -logKd/Ki=7.85,Ki=14nM BindingDB: Ki=14nM,IC50=23nM

External links

PDB	RCSB:2oz7, PDBe:2oz7, PDBj:2oz7
PDBsum	2oz7
PubMed	17311914
UniProt	P10275\|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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